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หัวข้อ : Autochthonous Leishmaniasis: an Emerging Zoonosis in Thailand

<div style="text-align: center;"> <strong>ABSTRACT</strong></div> <div style="text-align: center;"> &nbsp;</div> <div> There have been increasing reports of autochthonous leishmaniasis in Thailand during the past 5 years.</div> <div> All cases, excluding one, were caused by the novel Leishmania siamensis which have been reported only in</div> <div> Thailand. However, cutaneous autochthonous leishmaniasis caused by L. siamensis was recently described</div> <div> in horses of central Europe and the United States as well as a cow in Switzerland. It is believed that this is an</div> <div> emerging vector-borne zoonotic disease of potential public health concern in Thailand. The clinical</div> <div> manifestations can be visceral, cutaneous, as well as mixed visceral and cutaneous forms. Surprisingly, of 3</div> <div> patients with mixed visceral and cutaneous leishmaniasis, 2 initially presented with cutaneous leishmaniasis</div> <div> for few months and 4 years, respectively, before a development of visceral leishmaniasis. Regarding diagnostic</div> <div> investigations, the PCR test is practical and available in most university hospitals in Bangkok. The saliva</div> <div> specimen for PCR testing seems to be the most sensitive method, in comparison with other clinical specimens.</div> <div> To date, there are 3 potential sandfly vectors including Phlebotomus argentipes, P. major major, and</div> <div> Sergentomyia (Neophlebotomus) gemmea. There is an urgent need for comprehensive studies regarding</div> <div> potential sandfly vectors, reservoir animals, and case finding for both symptomatic and asymptomatic patients</div> <div> of leishmaniasis in Thailand. (J Infect Dis Antimicrob Agents 2014;31:1-8.)</div>